The spectrum of clinical syndromes termed chronic heart failure (CHF) represents the advanced, terminal stage of progression in a variety of heart conditions. A disturbing trend of increasing morbidity and mortality is placing considerable strain on the public's health and safety. The etiology of congestive heart failure is multifaceted, encompassing complex and diverse diseases, such as coronary heart disease, hypertension, diabetes, cardiomyopathy, and so forth. To unravel the mechanisms underlying CHF and create effective preventative and treatment strategies for diverse disease-induced CHF, the creation of animal CHF models tailored to specific etiologies is essential. Based on the classification of CHF etiology, this paper compiles animal models commonly utilized in the past decade. This paper details their applications in the context of traditional Chinese medicine (TCM) research, providing insights for exploring CHF pathogenesis and treatment. This work ultimately seeks to offer ideas for the modernization of TCM.
An overview of the 'eight trends' observed within the Chinese medicinal materials (CMM) sector in 2021 was presented in this paper, which also addressed the challenges in CMM production and suggested developmental directions. These eight trends, specifically, can be summarized as follows:(1) The CMM region's growth trajectory remained steady, leading some provinces to commence the release of localized Dao-di herb listings. upper respiratory infection New variety protection procedures were expedited, resulting in the cultivation of several exceptional plant varieties. The theory underlying ecological cultivation was expanded upon, and the demonstrable impact of ecological cultivation technology was substantial. malaria vaccine immunity Complete mechanization was achieved by some CMMs, which resulted in typical model cases. Growing numbers of cultivation bases began using the traceability platform, alongside the setting up of provincial internet trading platforms. Provincial-level regional brands proliferated as the construction of CMM industrial clusters gained momentum. Driven by the establishment of numerous agricultural business entities nationwide, a spectrum of methods was employed to fuel the intensified development of CMM. To complement the local TCM laws, management regulations for the catalogs of food and medicine homology substances were issued. Based upon this, a proposal for CMM manufacturing consisted of four suggestions. The national catalog of Dao-di herbs and the certification process for Dao-di herb production bases should be accelerated. In line with ecological prioritization, ecological planting of forest and grassland medicinal resources necessitates a heightened commitment to advanced technical research and promotion activities. Disaster prevention, at its core, demands heightened attention, and the development of advanced technical means for mitigating disaster impact should be prioritized. The national regular statistical system's scope must include the measurement of planted areas of routinely utilized CMMs.
Widespread understanding has developed regarding the complex interplay between the microbiome and traditional Chinese medicine (TCM). CID44216842 solubility dmso Microbiomics has experienced significant development in recent years, with new technologies, results, and theories arising from the advancements in high-throughput sequencing and multi-omics technologies. Inspired by previous research, this study introduces TCM microbiomics (TCMM), an interdisciplinary field exploring the functions and applications of microbiomes in herb resources, herb processing, herb storage, and clinical efficacy using advanced biological, ecological, and informatic tools. This subject examines the microbiome's organizational structures, operational functions, interactions, molecular mechanisms, and application techniques, all related to the quality, safety, and effectiveness of traditional Chinese medicine. To begin with, the TCMM concept's evolution was presented, with particular focus on the comprehensive grasp of microbiome complexity and totality offered by TCMM. In this review, we analyze the research and application of TCMM related to sustainable herb resource development, standardized and diversified herb fermentation, safe herb storage, and the scientific understanding of TCM theories and clinical effectiveness. In the end, the research strategies and methods of TCM microbiomics were detailed and developed from basic, applied, and systematic research perspectives. TCM modernization is expected to be spurred by TCMM, which will integrate TCM with cutting-edge scientific and technological advancements, thereby enhancing both the depth and breadth of TCM research.
As a traditional Chinese medicine dosage form, the lozenge plays a significant role. Across all Chinese dynasties, beginning with the Eastern Han, its usage has been documented and continually refined within traditional medical texts. The singular nature of the pharmaceutical procedures and the extent of their applicable uses are the primary drivers behind its rise, sustenance, and progression. The Chinese Pharmacopoeia has, up to the present, consistently included lozenge as a self-standing dosage form. Modern Chinese medicine pharmaceutics has imbued the lozenge with new significance, prompting a journey into its origins and an exploration of its value. This study examined the genesis and evolution of lozenges, contrasting them with similar pharmaceutical forms, scrutinizing the distinctions between ancient and contemporary lozenge formulations, and discussing the future potential and growth prospects of lozenges within the context of modern Chinese medicine preparations. The aim was to furnish insights for broader modern applications of this dosage form.
External therapies within Traditional Chinese Medicine (TCM) demonstrate a profound and enduring history, reflecting human ingenuity and experience. Early human societies recognized the effectiveness of fumigation, coating, and the application of tree branches and herbal stems in relieving scabies and eradicating parasites among workers, indicating the emergence of external therapeutic techniques. The pathogen's entry point is typically a bodily surface, allowing for external therapies to combat the illness. TCM surgery typically exhibits the characteristic of employing external therapies. External therapies in Traditional Chinese Medicine, focused on acupoints, influence the zang-fu organs through the networks of meridians and collaterals, ultimately restoring balance between yin and yang. This therapy's journey began in early societies, continuing through the formative periods of the Spring and Autumn and Warring States, receiving significant improvements during the Song and Ming dynasties, and achieving its full potential in the Qing dynasty. Due to the comprehensive efforts of historical experts, a mature understanding has been achieved. Studies in modern medicine reveal that Chinese medicinal products can bypass the liver's first-pass effect, reduce gastrointestinal irritation, and improve how well the body absorbs them. By stimulating acupoints and employing the theoretical framework of Chinese medicine, particularly the meridian and collateral theory, optimal results from Traditional Chinese Medicine and the combined effect of both are achieved. This action enables the regulation of qi and blood, and the restoration of the balance between yin and yang, thus contributing to its extensive use in treating diseases. Through a review of the literature, this paper summarized the use of external applications on acupoints, its impact on skin immunity, the regulation of neuro-inflammatory mechanisms, the connection between acupoint application and human circulatory networks, and the advancement of dosage form development. From this point, this research is expected to pave the way for additional investigations.
The circadian periodicity in the environment triggers an internal regulatory mechanism, the circadian rhythm, impacting pathological events, disease development, and the treatment response in mammals. This element substantially shapes the vulnerability, harm, and recuperation from ischemic stroke, along with the treatment effectiveness. Data suggests a critical role for circadian rhythms in controlling not just key physiological parameters, such as blood pressure and coagulation-fibrinolysis in ischemic stroke, but also in the immuno-inflammatory response orchestrated by glial cells and peripheral immune cells following ischemic damage, and the regulation of the neurovascular unit (NVU). From a molecular, cellular, and physiological perspective, this article explores the circadian pathways relevant to ischemic stroke. It underscores how circadian rhythms impact ischemic stroke's progression, neurovascular unit function, and the subsequent immune-inflammatory cascade. A review of traditional Chinese medicine's role in regulating circadian rhythms, along with a summary of research on its interventions, is presented to offer a valuable reference for future TCM research and molecular mechanism investigations into circadian rhythms.
Hair follicles (HFs) are populated by transit amplifying cells (TACs) that actively divide, rendering them extraordinarily sensitive to radiotherapy (RT). Clinically, the provision of effective treatments for radiotherapy-induced alopecia (RIA) is lacking.
This study investigated the impact and mechanisms behind the application of topical prostaglandin E2 (PGE2) in relation to the prevention of RIA.
Employing a live mouse model, we analyzed the response of proliferating high-frequency cells to irradiation, contrasting groups pre-treated with local PGE2 and those without. Within cultured HF cells originating from mice engineered to express a fluorescent ubiquitination-based cell cycle indicator, the impact of PGE2 on the cell cycle was determined. We also examined the protective influence of PGE2 and a cyclin-dependent kinases 4/6 (CDK4/6) inhibitor in relation to RIA.
By boosting the self-repair mechanisms of the heart's high frequency, the local cutaneous PGE2 injection brought about a decrease in RIA.